Gamma1 Heavy Chain Humanized (1-448) [Vh (Homo Sapiens Ighv3-15*07 (86.9%)--(Ighd) -Ighj1*01(90.9%), Cdr-Imgt [8.10.9] (26-33.51-60.99-107))(1-118) -Homo Sapiens Ighg1*01 (100%), G1M17,1 Ch1K120, Ch3 D12, L14 (Ch1 K120 (215) (119-216),Hinge 1-15 (217-231), Ch2 (232-341), Ch3 D12 (357), L14 (359) (342-446), Chs (447-448)) (119-448)], (221-220')-Disulfide With Kappa Light Chain Humanized (1'-220') [V-Kappa (Homo Sapiens Igkv2-24*01 (90.0%)-Igkj2*01 (100%), Cdr-Imgt [11.3.10] (27-37.55-57.94-103)) (1'-113') -Homo Sapiens Igkc*01 (100%), Km3, A45.1 (159), V101 (197) (114'-220')]; Dimer (227-227'':230-230'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Derived From The Cell Line Cho-K1, Glycoform Alfa
Non-Small Cell Lung Carcinoma
Explore 1,128 assets in Non-Small Cell Lung Carcinoma →Floatz Rating
CC46/100
Confidence
Indicative
Sponsor
AstraZeneca
Modality
monoclonal_antibody
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05061550CT.gov Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
59Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Non-Small Cell Lung Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Gamma1 Heavy Chain Humanized (1-448) [Vh (Homo Sapiens Ighv3-15*07 (86.9%)--(Ighd) -Ighj1*01(90.9%), Cdr-Imgt [8.10.9] (26-33.51-60.99-107))(1-118) -Homo Sapiens Ighg1*01 (100%), G1M17,1 Ch1K120, Ch3 D12, L14 (Ch1 K120 (215) (119-216),Hinge 1-15 (217-231), Ch2 (232-341), Ch3 D12 (357), L14 (359) (342-446), Chs (447-448)) (119-448)], (221-220')-Disulfide With Kappa Light Chain Humanized (1'-220') [V-Kappa (Homo Sapiens Igkv2-24*01 (90.0%)-Igkj2*01 (100%), Cdr-Imgt [11.3.10] (27-37.55-57.94-103)) (1'-113') -Homo Sapiens Igkc*01 (100%), Km3, A45.1 (159), V101 (197) (114'-220')]; Dimer (227-227'':230-230'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Derived From The Cell Line Cho-K1, Glycoform Alfa (this asset) | AstraZeneca | P2 | CC · 46 |
| Necitumumab | Jonsson Comprehensive Cancer Center | P3 | BBB |
| Glumetinib | Shanghai JMT-Bio Inc. | P3 | BBB |
| Veliparib | AbbVie | P3 | BBB |
| d-0316 | Betta Pharmaceuticals Co., Ltd. | P2/3 | BBB |
| Icotinib | The First Affiliated Hospital of Guangzhou Medical University | P4 | BBB |
| Zoledronate | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | P4 | BBB |
| Onartuzumab | Hoffmann-La Roche | P3 | BBB |
| Avitinib | Hangzhou ACEA Pharmaceutical Research Co., Ltd. | P3 | BBB |
+42 more in the Non-Small Cell Lung Carcinoma cohort
Other indications for Gamma1 Heavy Chain Humanized (1-448) [Vh (Homo Sapiens Ighv3-15*07 (86.9%)--(Ighd) -Ighj1*01(90.9%), Cdr-Imgt [8.10.9] (26-33.51-60.99-107))(1-118) -Homo Sapiens Ighg1*01 (100%), G1M17,1 Ch1K120, Ch3 D12, L14 (Ch1 K120 (215) (119-216),Hinge 1-15 (217-231), Ch2 (232-341), Ch3 D12 (357), L14 (359) (342-446), Chs (447-448)) (119-448)], (221-220')-Disulfide With Kappa Light Chain Humanized (1'-220') [V-Kappa (Homo Sapiens Igkv2-24*01 (90.0%)-Igkj2*01 (100%), Cdr-Imgt [11.3.10] (27-37.55-57.94-103)) (1'-113') -Homo Sapiens Igkc*01 (100%), Km3, A45.1 (159), V101 (197) (114'-220')]; Dimer (227-227'':230-230'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Derived From The Cell Line Cho-K1, Glycoform Alfa
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Soft Tissue Neoplasm | — | P2 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Gamma1 Heavy Chain Humanized (1-448) [Vh (Homo Sapiens Ighv3-15*07 (86.9%)--(Ighd) -Ighj1*01(90.9%), Cdr-Imgt [8.10.9] (26-33.51-60.99-107))(1-118) -Homo Sapiens Ighg1*01 (100%), G1M17,1 Ch1K120, Ch3 D12, L14 (Ch1 K120 (215) (119-216),Hinge 1-15 (217-231), Ch2 (232-341), Ch3 D12 (357), L14 (359) (342-446), Chs (447-448)) (119-448)], (221-220')-Disulfide With Kappa Light Chain Humanized (1'-220') [V-Kappa (Homo Sapiens Igkv2-24*01 (90.0%)-Igkj2*01 (100%), Cdr-Imgt [11.3.10] (27-37.55-57.94-103)) (1'-113') -Homo Sapiens Igkc*01 (100%), Km3, A45.1 (159), V101 (197) (114'-220')]; Dimer (227-227'':230-230'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Derived From The Cell Line Cho-K1, Glycoform Alfa in Non-Small Cell Lung Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/gamma1-heavy-chain-humanized-1-448-vh-homo-sapiens-ighv3-1507-869-ighd-ighj101909-cdr-imgt-8109-26-3351-6099-1071-118-homo-sapiens-ighg101-100-g1m171-ch1k120-ch3-d12-l14-ch1-k120-215-119-216hinge-1-15-217-231-ch2-232-341-ch3-d12-357-l14-359-342-446-chs-447-448-119-448-221-220-disulfide-with-kappa-light-chain-humanized-1-220-v-kappa-homo-sapiens-igkv2-2401-900-igkj201-100-cdr-imgt-11310-27-3755-5794-103-1-113-homo-sapiens-igkc01-100-km3-a451-159-v101-197-114-220-dimer-227-227230-230-bisdisulfide-produced-in-chinese-hamster-ovary-cho-cells-derived-from-the-cell-line-cho-k1-glycoform-alfa-non-small-cell-lung-carcinoma
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