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Gamma1 Heavy Chain Humanized (1-448) [Vh (Homo Sapiens Ighv3-15*07 (86.9%)--(Ighd) -Ighj1*01(90.9%), Cdr-Imgt [8.10.9] (26-33.51-60.99-107))(1-118) -Homo Sapiens Ighg1*01 (100%), G1M17,1 Ch1K120, Ch3 D12, L14 (Ch1 K120 (215) (119-216),Hinge 1-15 (217-231), Ch2 (232-341), Ch3 D12 (357), L14 (359) (342-446), Chs (447-448)) (119-448)], (221-220')-Disulfide With Kappa Light Chain Humanized (1'-220') [V-Kappa (Homo Sapiens Igkv2-24*01 (90.0%)-Igkj2*01 (100%), Cdr-Imgt [11.3.10] (27-37.55-57.94-103)) (1'-113') -Homo Sapiens Igkc*01 (100%), Km3, A45.1 (159), V101 (197) (114'-220')]; Dimer (227-227'':230-230'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Derived From The Cell Line Cho-K1, Glycoform Alfa

Soft Tissue Neoplasm

Explore 5 assets in Soft Tissue Neoplasm →
Floatz Rating
CCC53/100
Confidence
Indicative
v0.2
Sponsor
AstraZeneca
Modality
monoclonal_antibody
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2

Clinical Evidence

Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Moderate confidence
Detailed axis rationale is planned and will be published soon.
TrialPhaseStatusNPrimary endpointReadout
NCT04999969CT.gov
Safety, Pharmacokinetics and Clinical Activity of AZD0171 in Combination With Durvalumab and Chemotherapy in Locally Advanced or Metastatic Solid Tumours
—Active Not Recruiting———

Competitive Position

Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Indicative
Detailed axis rationale is planned and will be published soon.

Same indication · Soft Tissue Neoplasm

AssetSponsorPhaseRating
Gamma1 Heavy Chain Humanized (1-448) [Vh (Homo Sapiens Ighv3-15*07 (86.9%)--(Ighd) -Ighj1*01(90.9%), Cdr-Imgt [8.10.9] (26-33.51-60.99-107))(1-118) -Homo Sapiens Ighg1*01 (100%), G1M17,1 Ch1K120, Ch3 D12, L14 (Ch1 K120 (215) (119-216),Hinge 1-15 (217-231), Ch2 (232-341), Ch3 D12 (357), L14 (359) (342-446), Chs (447-448)) (119-448)], (221-220')-Disulfide With Kappa Light Chain Humanized (1'-220') [V-Kappa (Homo Sapiens Igkv2-24*01 (90.0%)-Igkj2*01 (100%), Cdr-Imgt [11.3.10] (27-37.55-57.94-103)) (1'-113') -Homo Sapiens Igkc*01 (100%), Km3, A45.1 (159), V101 (197) (114'-220')]; Dimer (227-227'':230-230'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Derived From The Cell Line Cho-K1, Glycoform Alfa (this asset)AstraZenecaP2CCC · 53
DurvalumabAstraZenecaP2CCC
vb10.neoNykode Therapeutics ASAP1/2CCC
Immunoglobulin G4, Anti-(Human Programmed Cell Death Protein 1) (Human Monoclonal Regn2810 Heavy Chain), Disulfide With Human Monoclonal Regn2810 .Kappa.-Chain, DimerAnkyra Therapeutics, IncP1CC
89-zr-dfo-star polyethylene glycolRobert Flavell, MD, PhDP1CC
TemsirolimusM.D. Anderson Cancer CenterP1CC
CetuximabM.D. Anderson Cancer CenterP1CC
Valproic AcidM.D. Anderson Cancer CenterP1CC
Tolododekin AlfaAnkyra Therapeutics, IncP1CC

+3 more in the Soft Tissue Neoplasm cohort

Other indications for Gamma1 Heavy Chain Humanized (1-448) [Vh (Homo Sapiens Ighv3-15*07 (86.9%)--(Ighd) -Ighj1*01(90.9%), Cdr-Imgt [8.10.9] (26-33.51-60.99-107))(1-118) -Homo Sapiens Ighg1*01 (100%), G1M17,1 Ch1K120, Ch3 D12, L14 (Ch1 K120 (215) (119-216),Hinge 1-15 (217-231), Ch2 (232-341), Ch3 D12 (357), L14 (359) (342-446), Chs (447-448)) (119-448)], (221-220')-Disulfide With Kappa Light Chain Humanized (1'-220') [V-Kappa (Homo Sapiens Igkv2-24*01 (90.0%)-Igkj2*01 (100%), Cdr-Imgt [11.3.10] (27-37.55-57.94-103)) (1'-113') -Homo Sapiens Igkc*01 (100%), Km3, A45.1 (159), V101 (197) (114'-220')]; Dimer (227-227'':230-230'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Derived From The Cell Line Cho-K1, Glycoform Alfa

IndicationSponsorPhaseRating
Non-Small Cell Lung Carcinoma—P2CC · 46

Scientific Foundation

Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR

Planned for methodology v0.2.

Development Feasibility

How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR

Planned for methodology v0.2.

Commercial Opportunity

Commercial prize: addressable population, unmet need, and the value case for the indication.
NR

Planned for methodology v0.2.

IP & Exclusivity

Exclusivity position, covering patent protection and freedom-to-operate runway.
NR

Planned for methodology v0.2.

Manufacturing & Supply

Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR

Planned for methodology v0.2.

Related assets

Citation

Floatz Terminal. Gamma1 Heavy Chain Humanized (1-448) [Vh (Homo Sapiens Ighv3-15*07 (86.9%)--(Ighd) -Ighj1*01(90.9%), Cdr-Imgt [8.10.9] (26-33.51-60.99-107))(1-118) -Homo Sapiens Ighg1*01 (100%), G1M17,1 Ch1K120, Ch3 D12, L14 (Ch1 K120 (215) (119-216),Hinge 1-15 (217-231), Ch2 (232-341), Ch3 D12 (357), L14 (359) (342-446), Chs (447-448)) (119-448)], (221-220')-Disulfide With Kappa Light Chain Humanized (1'-220') [V-Kappa (Homo Sapiens Igkv2-24*01 (90.0%)-Igkj2*01 (100%), Cdr-Imgt [11.3.10] (27-37.55-57.94-103)) (1'-113') -Homo Sapiens Igkc*01 (100%), Km3, A45.1 (159), V101 (197) (114'-220')]; Dimer (227-227'':230-230'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Derived From The Cell Line Cho-K1, Glycoform Alfa in Soft Tissue Neoplasm. Methodology v0.2.
Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026.
Accessed July 14, 2026.
https://terminal.floatz.ai/assets/gamma1-heavy-chain-humanized-1-448-vh-homo-sapiens-ighv3-1507-869-ighd-ighj101909-cdr-imgt-8109-26-3351-6099-1071-118-homo-sapiens-ighg101-100-g1m171-ch1k120-ch3-d12-l14-ch1-k120-215-119-216hinge-1-15-217-231-ch2-232-341-ch3-d12-357-l14-359-342-446-chs-447-448-119-448-221-220-disulfide-with-kappa-light-chain-humanized-1-220-v-kappa-homo-sapiens-igkv2-2401-900-igkj201-100-cdr-imgt-11310-27-3755-5794-103-1-113-homo-sapiens-igkc01-100-km3-a451-159-v101-197-114-220-dimer-227-227230-230-bisdisulfide-produced-in-chinese-hamster-ovary-cho-cells-derived-from-the-cell-line-cho-k1-glycoform-alfa-soft-tissue-neoplasm

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