Human Culture Expanded Genetically Modified Autologous T Cells For Cell-Based Gene Therapy. Cells Are Derived From Isolated Blood Of The Patient And Are Transduced With Non-Replicative Self-Inactivating (Sin) Human Immunodeficiency Virus Type 1 (Hiv-1) Based Lentiviral Vector (Lvv) Pseudotyped With The Vesicular Stomatitis Virus Glycoprotein G (Vsv-G) Envelope Protein, And Encoding The C11D5.3 Anti-Tnf Receptor Superfamily Member 17 (Tnfrsf17, Bcma) Single Chain Variable Fragment (Scfv) Cd8/4-1Bb/Cd3Zeta Chimeric Antigen Receptor (Car) Under The Transcriptional Control Of The Myeloproliferative Sarcoma Virus Enhancer, Negative Control Region Deleted, Dl587Rev Primer-Binding Site Substituted (Mnd) Promote
Large B-Cell Lymphoma
Explore 71 assets in Large B-Cell Lymphoma →Floatz Rating
CCC51/100
Confidence
Indicative
Sponsor
Masonic Cancer Center, University of Minnesota
Modality
Cell therapy
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03642626CT.gov MT2017-45: CAR-T Cell Therapy for Heme Malignancies | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Large B-Cell Lymphoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Human Culture Expanded Genetically Modified Autologous T Cells For Cell-Based Gene Therapy. Cells Are Derived From Isolated Blood Of The Patient And Are Transduced With Non-Replicative Self-Inactivating (Sin) Human Immunodeficiency Virus Type 1 (Hiv-1) Based Lentiviral Vector (Lvv) Pseudotyped With The Vesicular Stomatitis Virus Glycoprotein G (Vsv-G) Envelope Protein, And Encoding The C11D5.3 Anti-Tnf Receptor Superfamily Member 17 (Tnfrsf17, Bcma) Single Chain Variable Fragment (Scfv) Cd8/4-1Bb/Cd3Zeta Chimeric Antigen Receptor (Car) Under The Transcriptional Control Of The Myeloproliferative Sarcoma Virus Enhancer, Negative Control Region Deleted, Dl587Rev Primer-Binding Site Substituted (Mnd) Promote (this asset) | Masonic Cancer Center, University of Minnesota | P2 | CCC · 51 |
| Axicabtagene Ciloleucel | Zhejiang Cancer Hospital | P4 | BB |
| Cyclophosphamide | M.D. Anderson Cancer Center | P4 | BB |
| Fludarabine | M.D. Anderson Cancer Center | P4 | BB |
| Etoposide | University of California, Davis | P2/3 | BB |
| Prednisone | Ruijin Hospital | P3 | BB |
| Adriamycin | Ruijin Hospital | P3 | BB |
| Rituximab | Ruijin Hospital | P3 | B |
| Golcadomide | Allison Winter | P3 | B |
+41 more in the Large B-Cell Lymphoma cohort
Other indications for Human Culture Expanded Genetically Modified Autologous T Cells For Cell-Based Gene Therapy. Cells Are Derived From Isolated Blood Of The Patient And Are Transduced With Non-Replicative Self-Inactivating (Sin) Human Immunodeficiency Virus Type 1 (Hiv-1) Based Lentiviral Vector (Lvv) Pseudotyped With The Vesicular Stomatitis Virus Glycoprotein G (Vsv-G) Envelope Protein, And Encoding The C11D5.3 Anti-Tnf Receptor Superfamily Member 17 (Tnfrsf17, Bcma) Single Chain Variable Fragment (Scfv) Cd8/4-1Bb/Cd3Zeta Chimeric Antigen Receptor (Car) Under The Transcriptional Control Of The Myeloproliferative Sarcoma Virus Enhancer, Negative Control Region Deleted, Dl587Rev Primer-Binding Site Substituted (Mnd) Promote
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Plasma Cell Myeloma | — | P3 | BB · 66 |
| Acute Lymphoblastic Leukemia | — | P2 | CCC · 48 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Human Culture Expanded Genetically Modified Autologous T Cells For Cell-Based Gene Therapy. Cells Are Derived From Isolated Blood Of The Patient And Are Transduced With Non-Replicative Self-Inactivating (Sin) Human Immunodeficiency Virus Type 1 (Hiv-1) Based Lentiviral Vector (Lvv) Pseudotyped With The Vesicular Stomatitis Virus Glycoprotein G (Vsv-G) Envelope Protein, And Encoding The C11D5.3 Anti-Tnf Receptor Superfamily Member 17 (Tnfrsf17, Bcma) Single Chain Variable Fragment (Scfv) Cd8/4-1Bb/Cd3Zeta Chimeric Antigen Receptor (Car) Under The Transcriptional Control Of The Myeloproliferative Sarcoma Virus Enhancer, Negative Control Region Deleted, Dl587Rev Primer-Binding Site Substituted (Mnd) Promote in Large B-Cell Lymphoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/human-culture-expanded-genetically-modified-autologous-t-cells-for-cell-based-gene-therapy-cells-are-derived-from-isolated-blood-of-the-patient-and-are-transduced-with-non-replicative-self-inactivating-sin-human-immunodeficiency-virus-type-1-hiv-1-based-lentiviral-vector-lvv-pseudotyped-with-the-vesicular-stomatitis-virus-glycoprotein-g-vsv-g-envelope-protein-and-encoding-the-c11d53-anti-tnf-receptor-superfamily-member-17-tnfrsf17-bcma-single-chain-variable-fragment-scfv-cd84-1bbcd3zeta-chimeric-antigen-receptor-car-under-the-transcriptional-control-of-the-myeloproliferative-sarcoma-virus-enhancer-negative-control-region-deleted-dl587rev-primer-binding-site-substituted-mnd-promote-large-b-cell-lymphoma
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