71 assets in Large B-Cell Lymphoma

Axicabtagene Ciloleucel

Cyclophosphamide

Fludarabine

Etoposide

Adriamycin

Prednisone

Golcadomide

Lenalidomide

Rituximab

Surovatamig

Polatuzumab Vedotin

Venetoclax

Allo-501A

Allo-647

Dexasone

(+)-Vincristine

Zanubrutinib

Acalabrutinib

Immunoglobulin G1 (149-Glutamic Acid,215-Glutamic Acid,461-Alanine,462-Alanine,556-Glycine,581-Cysteine,593-Tryptophan), Anti-(Human Cd20 Antigen) (Human-Mus Musculus Monoclonal Rg6026 Vh-Ch1 Fragment) Fusion Protein With Peptide (Synthetic 10-Amino Acid Linker) Fusion Protein With Immunoglobulin Anti-(Human Cd3 Antigen .Epsilon.-Chain) (Human-Mus Musculus Monoclonal Rg6026 Heavy Chain Vl(.Lambda.)-Ch1-Ch2-Ch3), (222->219''')-Disulfide With Immunoglobulin Anti-(Human Cd20 Antigen) (Human-Mus Musculus Monoclonal Rg6026 .Kappa.-Chain (128-Arginine,129-Lysine)) And (447->232'')-Disulfide With Immunoglobulin Anti-(Human Cd3 Antigen .Epsilon.-Chain) (Human-Mus Musculus Monoclonal Rg6026 Light Chain Vh-Cl(.Kappa.)), (453->228'), (456->231'), (581->351')-Tris(Disulfide) With Immunoglobulin G1 (149-Glutamic Acid,215-Glutamic Acid,236-Alanine,237-Alanine,331-Glycine,351-Cysteine,368-Serine,370-Alanine,409-Valine) Anti-(Human Cd20 Antigen) (Human-Mus Musculus Monoclonal Rg6026 .Gamma.1-Chain) Disulfide With Human-Mus Musculus Monoclonal Rg6026 .Kappa.-Chain (128-Arginine,129-Lysine)

Rondecabtagene Autoleucel

Obinutuzumab

Tafasitamab

Vincristine Sulfate

Oxaliplatin

Mosunetuzumab

Jcar-017 Cd19-Specific Chimeric Antigen Receptor

cd19-ucart

Decitabine

Firi-Cel

Rimegepant

Anti-Cd19 Car T-Cells

Autologous Cd4+ And Cd8+ T Cells, Enriched From Peripheral Blood Mononuclear Cells (Pbmcs) Transduced With A Nonreplicative Self-Inactivating (Sin) Lentiviral Vector Encoding A Chimeric Antigen Receptor (Car) Consisting Of The Human Cd19-Specific Scfv, An Lgg4 Hinge Region, Cd28 Transmembrane Domain, Cd137 (4-1Bb) Co-Stimulatory Domain And Cd3 Zeta Signalling Domain, Under The Control Of A Hybrid Elongation Factor 1 Alpha (Ef1.Alpha.) And Human T Cell Leukemia Virus Type 1(Htlv-1) Regulatory Element Promoter And Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element (Wpre). The Vector Genome Also Encodes A Truncated Human Epidermal Growth Factor Receptor (Egfrt) That Is Co-Expressed With The Car And Cleaved From It By The T2A Self-Cleaving Peptide. The Vector Genome Also Contains A Splice Donor, A Fragment Of Gag, A Rev Response Element (Rre), A Mutated Central Polypurine Tract (Cppt), And A Splice Acceptor

Brexucabtagene Autoleucel

Breyanzi Injectable Product

cd70.car nk cells

Cemacabtagene Ansegedleucel

Dfo-Atezolizumab Zr-89

Emapalumab

Epcoritamab

Human Culture Expanded Genetically Modified Autologous T Cells For Cell-Based Gene Therapy. Cells Are Derived From Isolated Blood Of The Patient And Are Transduced With Non-Replicative Self-Inactivating (Sin) Human Immunodeficiency Virus Type 1 (Hiv-1) Based Lentiviral Vector (Lvv) Pseudotyped With The Vesicular Stomatitis Virus Glycoprotein G (Vsv-G) Envelope Protein, And Encoding The C11D5.3 Anti-Tnf Receptor Superfamily Member 17 (Tnfrsf17, Bcma) Single Chain Variable Fragment (Scfv) Cd8/4-1Bb/Cd3Zeta Chimeric Antigen Receptor (Car) Under The Transcriptional Control Of The Myeloproliferative Sarcoma Virus Enhancer, Negative Control Region Deleted, Dl587Rev Primer-Binding Site Substituted (Mnd) Promote

Tislelizumab

Wztl-002 Car T-Cells

Loncastuximab Tesirine

Rimiducid

Pidnarulex

Poseltinib

Aleta-001

Autologous T Cells Obtained From Peripheral Blood Mononuclear Cells By Leukapheresis, Transduced With A Self-Inactivating, Nonreplicating Lentiviral Vector, Encoding A T Cell Chimeric Antigen Receptor Targeting Cd19. The Expressed Transgene Comprises A Cd8? Leader Sequence, A Murine Anti-Cd19 Single Chain Variable Fragment (Scfv) Derived From The Mouse Hybridoma Fmc63, A Cd8? Hinge And Transmembrane Region, And A 4-1Bb (Cd137) And Cd3? (Tcr?) Signaling Domain And Is Under Control Of The Elongation Factor 1 Alpha (Ef1?) Promoter. The Construct Is Flanked By 5' And 3' Long Terminal Repeats (Ltrs) And Also Contains A ? Packaging Signal, A Rev Response Element (Rre), A Central Polypurine Tract (Cppt) Sequence And An Optimized Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element (Wpre). The Leukapheresis Material Is Enriched For Cd4/Cd8 T Cells By Positive Immunoselection, Activated By Cd3 And Cd28 Agonists And Transduced With The Vector. Without Further Cell Propagation, The T Cells Are Washed, Formulated For Infusion, And Cryopreserved. The Substance Is Composed Of ?80% T Cells And ?1% B Cells, With A Mixture Of Transgene Positive (>3.4%) And Negative T Cells. The Cd4+ And Cd8+ Naïve T Cell Subsets (Cd45Ra+Ccr7+) Present In The Leukapheresis Material Are Largely Retained

cd19 specific chimeric antigen receptor t cell

ctx112