Human Hyaluronidase Isozyme-5 (Hyal5, Sperm Adhesion Molecule 1, Spam1, Hyaluronidase Ph-20, Ec:3.2.1.35) Fragment (3-433, 1-431 In The Current Sequence) Engineered Variant With The Structural Domain Replaced By The Corresponding Region Of Human Hyaluronidase Isozyme-1 (Hyal1)(<Sup>306</Sup>Tlsimrsmkscllddnymeti<Sup>326</Sup>><Sup>304</Sup>Swentrtkescqaikeymdtt<Sup>324</Sup>), Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Dg44, Glycoform Alfa
Non-Small Cell Lung Carcinoma
Explore 1,128 assets in Non-Small Cell Lung Carcinoma →Floatz Rating
BB66/100
Confidence
Indicative
Sponsor
Merck Sharp & Dohme LLC
Modality
protein_peptide
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
52Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07513376CT.gov A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014) | — | Recruiting | — | — | — |
NCT07190248CT.gov A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007) | — | Recruiting | — | — | — |
NCT06698042CT.gov A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84) | — | Active Not Recruiting | — | — | — |
NCT06099782CT.gov A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11) | — | Active Not Recruiting | — | — | — |
NCT06212752CT.gov A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)-Japan Extension | — | Active Not Recruiting | — | — | — |
NCT05722015CT.gov A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77) | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Non-Small Cell Lung Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Human Hyaluronidase Isozyme-5 (Hyal5, Sperm Adhesion Molecule 1, Spam1, Hyaluronidase Ph-20, Ec:3.2.1.35) Fragment (3-433, 1-431 In The Current Sequence) Engineered Variant With The Structural Domain Replaced By The Corresponding Region Of Human Hyaluronidase Isozyme-1 (Hyal1)(<Sup>306</Sup>Tlsimrsmkscllddnymeti<Sup>326</Sup>><Sup>304</Sup>Swentrtkescqaikeymdtt<Sup>324</Sup>), Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Dg44, Glycoform Alfa (this asset) | Merck Sharp & Dohme LLC | P3 | BB · 66 |
| Necitumumab | Jonsson Comprehensive Cancer Center | P3 | BBB |
| Glumetinib | Shanghai JMT-Bio Inc. | P3 | BBB |
| Veliparib | AbbVie | P3 | BBB |
| d-0316 | Betta Pharmaceuticals Co., Ltd. | P2/3 | BBB |
| Icotinib | The First Affiliated Hospital of Guangzhou Medical University | P4 | BBB |
| Zoledronate | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | P4 | BBB |
| Onartuzumab | Hoffmann-La Roche | P3 | BBB |
| Avitinib | Hangzhou ACEA Pharmaceutical Research Co., Ltd. | P3 | BBB |
+42 more in the Non-Small Cell Lung Carcinoma cohort
Other indications for Human Hyaluronidase Isozyme-5 (Hyal5, Sperm Adhesion Molecule 1, Spam1, Hyaluronidase Ph-20, Ec:3.2.1.35) Fragment (3-433, 1-431 In The Current Sequence) Engineered Variant With The Structural Domain Replaced By The Corresponding Region Of Human Hyaluronidase Isozyme-1 (Hyal1)(<Sup>306</Sup>Tlsimrsmkscllddnymeti<Sup>326</Sup>><Sup>304</Sup>Swentrtkescqaikeymdtt<Sup>324</Sup>), Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Dg44, Glycoform Alfa
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Plasma Cell Myeloma | — | P2 | CC · 46 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Human Hyaluronidase Isozyme-5 (Hyal5, Sperm Adhesion Molecule 1, Spam1, Hyaluronidase Ph-20, Ec:3.2.1.35) Fragment (3-433, 1-431 In The Current Sequence) Engineered Variant With The Structural Domain Replaced By The Corresponding Region Of Human Hyaluronidase Isozyme-1 (Hyal1)(<Sup>306</Sup>Tlsimrsmkscllddnymeti<Sup>326</Sup>><Sup>304</Sup>Swentrtkescqaikeymdtt<Sup>324</Sup>), Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Dg44, Glycoform Alfa in Non-Small Cell Lung Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/human-hyaluronidase-isozyme-5-hyal5-sperm-adhesion-molecule-1-spam1-hyaluronidase-ph-20-ec32135-fragment-3-433-1-431-in-the-current-sequence-engineered-variant-with-the-structural-domain-replaced-by-the-corresponding-region-of-human-hyaluronidase-isozyme-1-hyal1sup306suptlsimrsmkscllddnymetisup326supsup304supswentrtkescqaikeymdttsup324sup-produced-in-chinese-hamster-ovary-cho-cells-cell-line-dg44-glycoform-alfa-non-small-cell-lung-carcinoma
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