Human Hyaluronidase Isozyme-5 (Hyal5, Sperm Adhesion Molecule 1, Spam1, Hyaluronidase Ph-20, Ec:3.2.1.35) Fragment (3-433, 1-431 In The Current Sequence) Engineered Variant With The Structural Domain Replaced By The Corresponding Region Of Human Hyaluronidase Isozyme-1 (Hyal1)(<Sup>306</Sup>Tlsimrsmkscllddnymeti<Sup>326</Sup>><Sup>304</Sup>Swentrtkescqaikeymdtt<Sup>324</Sup>), Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Dg44, Glycoform Alfa
Plasma Cell Myeloma
Explore 475 assets in Plasma Cell Myeloma →Floatz Rating
CC46/100
Confidence
Indicative
Sponsor
Barbara Ann Karmanos Cancer Institute
Modality
protein_peptide
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06107738CT.gov Iberdomide and Daratumumab As Maintenance Therapy After an Autologous Stem Cell Transplant for Multiple Myeloma | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
59High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Plasma Cell Myeloma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Human Hyaluronidase Isozyme-5 (Hyal5, Sperm Adhesion Molecule 1, Spam1, Hyaluronidase Ph-20, Ec:3.2.1.35) Fragment (3-433, 1-431 In The Current Sequence) Engineered Variant With The Structural Domain Replaced By The Corresponding Region Of Human Hyaluronidase Isozyme-1 (Hyal1)(<Sup>306</Sup>Tlsimrsmkscllddnymeti<Sup>326</Sup>><Sup>304</Sup>Swentrtkescqaikeymdtt<Sup>324</Sup>), Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Dg44, Glycoform Alfa (this asset) | Barbara Ann Karmanos Cancer Institute | P2 | CC · 46 |
| Hyaluronidase Fihj | Massachusetts General Hospital | P4 | BBB |
| Filanesib | PETHEMA Foundation | P2 | BBB |
| Vincristine Sulfate | Roswell Park Cancer Institute | P3 | BBB |
| Cyclosporin A | Seoul National University Hospital | P3 | BBB |
| Anti-Human T-Lymphocyte Immunoglobulin, Rabbit | University of Birmingham | P4 | BBB |
| Epoetin Alfa | Mayo Clinic | P3 | BB |
| Arsenic Trioxide | Duke University | P2 | BB |
| Sorafenib | OHSU Knight Cancer Institute | P2 | BB |
+42 more in the Plasma Cell Myeloma cohort
Other indications for Human Hyaluronidase Isozyme-5 (Hyal5, Sperm Adhesion Molecule 1, Spam1, Hyaluronidase Ph-20, Ec:3.2.1.35) Fragment (3-433, 1-431 In The Current Sequence) Engineered Variant With The Structural Domain Replaced By The Corresponding Region Of Human Hyaluronidase Isozyme-1 (Hyal1)(<Sup>306</Sup>Tlsimrsmkscllddnymeti<Sup>326</Sup>><Sup>304</Sup>Swentrtkescqaikeymdtt<Sup>324</Sup>), Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Dg44, Glycoform Alfa
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Non-Small Cell Lung Carcinoma | — | P3 | BB · 66 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Human Hyaluronidase Isozyme-5 (Hyal5, Sperm Adhesion Molecule 1, Spam1, Hyaluronidase Ph-20, Ec:3.2.1.35) Fragment (3-433, 1-431 In The Current Sequence) Engineered Variant With The Structural Domain Replaced By The Corresponding Region Of Human Hyaluronidase Isozyme-1 (Hyal1)(<Sup>306</Sup>Tlsimrsmkscllddnymeti<Sup>326</Sup>><Sup>304</Sup>Swentrtkescqaikeymdtt<Sup>324</Sup>), Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Dg44, Glycoform Alfa in Plasma Cell Myeloma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/human-hyaluronidase-isozyme-5-hyal5-sperm-adhesion-molecule-1-spam1-hyaluronidase-ph-20-ec32135-fragment-3-433-1-431-in-the-current-sequence-engineered-variant-with-the-structural-domain-replaced-by-the-corresponding-region-of-human-hyaluronidase-isozyme-1-hyal1sup306suptlsimrsmkscllddnymetisup326supsup304supswentrtkescqaikeymdttsup324sup-produced-in-chinese-hamster-ovary-cho-cells-cell-line-dg44-glycoform-alfa-plasma-cell-myeloma
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