L-Acetyl Carnitine
Amyotrophic Lateral Sclerosis
Explore 148 assets in Amyotrophic Lateral Sclerosis →Floatz Rating
CCC52/100
Confidence
Indicative
Sponsor
Mario Negri Institute for Pharmacological Research
Modality
Small molecule
Development Phase
Phase 2/3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
42Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06126315CT.gov Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Amyotrophic Lateral Sclerosis
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| L-Acetyl Carnitine (this asset) | Mario Negri Institute for Pharmacological Research | P2/3 | CCC · 52 |
| Taurursodiol | Amylyx Pharmaceuticals Inc. | P3 | BBB |
| Tofersen | Biogen | P4 | BBB |
| Mexiletine | Bjorn Oskarsson, MD | P4 | BB |
| Riluzole | AB Science | P4 | BB |
| Diacetyl(N(4)-Methylthiosemicarbazonato) Copper (Ii) | Collaborative Medicinal Development Pty Limited | P2/3 | BB |
| Autologous Mesenchymal Stromal Cells Secreting Neurotrophic Factors | Brainstorm-Cell Therapeutics | P3 | BB |
| mt-1186 | Tanabe Pharma Corporation | P3 | BB |
| Mci-186 | Tanabe Pharma Corporation | P3 | BB |
+42 more in the Amyotrophic Lateral Sclerosis cohort
Other indications for L-Acetyl Carnitine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Migraine Disorder | — | P4 | B · 62 |
| Alzheimer Disease | — | P4 | B · 58 |
| Bipolar Depression | — | P2 | B · 57 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. L-Acetyl Carnitine in Amyotrophic Lateral Sclerosis. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/l-acetyl-carnitine-amyotrophic-lateral-sclerosis
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