Floatz Rating
B59/100
Confidence
Indicative
Sponsor
Odense University Hospital
Modality
Small molecule
Development Phase
Phase 3
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
44Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT02266849CT.gov Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded Cross-over Study | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Short Bowel Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Loperamide (this asset) | Odense University Hospital | P3 | B · 59 |
| Serostim | Northwestern University | P4 | BB |
| Glepaglutide | Zealand Pharma | P3 | B |
| Apraglutide | VectivBio AG | P2 | B |
| Crofelemer | Napo Therapeutics, S.p.A. | P2 | CCC |
| Mono-[2,5,7,8-Tetramethyl-2-(4,8,12-Trimethyltridecyl)-6-Chromanyl] Succinate Polyethylene Glycol Monoester | Boston Children's Hospital | P2 | CCC |
| Glucagon-Like Peptide 2 | Alberta Children's Hospital | P1/2 | CCC |
| fe203799 | GlyPharma Therapeutics | P1/2 | NR |
Other indications for Loperamide
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Diarrheal Disease | — | P3 | BB · 66 |
| Relapsing-Remitting Multiple Sclerosis | — | P4 | B · 62 |
| Breast Cancer | — | P2/3 | B · 59 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Loperamide in Short Bowel Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/loperamide-short-bowel-syndrome
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