Floatz Rating
BB64/100
Confidence
Indicative
Sponsor
Pakistan Institute of Medical Sciences
Modality
Small molecule
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
49Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05626140CT.gov COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA | — | Completed | — | — | — |
NCT00163553CT.gov Neuraxial Pethidine After Lumbar Surgery Trial | — | Unknown | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Sciatica
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Meperidine (this asset) | Pakistan Institute of Medical Sciences | P3 | BB · 64 |
| Dexasone | University of Miami | P4 | BBB |
| Lidocaine | C.L.A.Vleggeert-Lankamp | P4 | BBB |
| Nepenthe | Akdeniz University | P4 | BB |
| Naproxen | Ostfold Hospital Trust | P4 | BB |
| (Rs)-Ketoprofen | University Hospital, Grenoble | P4 | BB |
| Prednisone | Kaiser Permanente | P3 | BB |
| Ibuprofen | St Joseph University, Beirut, Lebanon | P4 | BB |
| Pentoxifylline | St Joseph University, Beirut, Lebanon | P4 | BB |
+36 more in the Sciatica cohort
Other indications for Meperidine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Choledocholithiasis | — | P4 | BBB · 72 |
| Pancreatitis | — | P4 | BB · 68 |
| Hepatitis | — | P4 | BB · 68 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Meperidine in Sciatica. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/meperidine-sciatica
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