Pteroylmonoglutamic Acid Hydrolase G2
Acute Lymphoblastic Leukemia
Explore 247 assets in Acute Lymphoblastic Leukemia →Floatz Rating
BB64/100
Confidence
Indicative
Sponsor
Nordic Society for Pediatric Hematology and Oncology
Modality
protein_peptide
Development Phase
Phase 3
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
49Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01305655CT.gov Glucarpidase Effect on Severe Delayed HDM-clearance in Children Treated With High-dose Mtx in ALL | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Acute Lymphoblastic Leukemia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pteroylmonoglutamic Acid Hydrolase G2 (this asset) | Nordic Society for Pediatric Hematology and Oncology | P3 | BB · 64 |
| Gm-Csf | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | P4 | BBB |
| Peripheral Blood Stem Cells, Allogeneic, Cd34 Positive | Fred Hutchinson Cancer Center | P2/3 | BBB |
| Equine Atg | Instituto Nacional de Cancer, Brazil | P3 | BBB |
| Thioguanine Anhydrous | St. Jude Children's Research Hospital | P4 | BBB |
| Mercaptopurine Anhydrous | Dana-Farber Cancer Institute | P4 | BB |
| Cyclophosphamide | Sawa Ito, MD | P4 | BB |
| Vincristine Sulfate | Children's Oncology Group | P3 | BB |
| Asparaginase | Centre Hospitalier Universitaire de Nice | P4 | BB |
+42 more in the Acute Lymphoblastic Leukemia cohort
Other indications for Pteroylmonoglutamic Acid Hydrolase G2
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Lymphoma | — | P2 | B · 59 |
| Toxic Encephalopathy | — | P1/2 | CCC · 52 |
| Mucositis | — | P1/2 | CCC · 52 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- Gm-CsfXinhua Hospital, Shanghai Jiao Tong University School of MedicineBBB
- Peripheral Blood Stem Cells, Allogeneic, Cd34 PositiveFred Hutchinson Cancer CenterBBB
- Equine AtgInstituto Nacional de Cancer, BrazilBBB
- Thioguanine AnhydrousSt. Jude Children's Research HospitalBBB
- Mercaptopurine AnhydrousDana-Farber Cancer InstituteBB
Citation
Floatz Terminal. Pteroylmonoglutamic Acid Hydrolase G2 in Acute Lymphoblastic Leukemia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pteroylmonoglutamic-acid-hydrolase-g2-acute-lymphoblastic-leukemia
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