Floatz Rating
CCC52/100
Confidence
Indicative
Sponsor
University College, London
Modality
protein_peptide
Development Phase
Phase 1/2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
37Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT00727831CT.gov Methotrexate, Glucarpidase, and Leucovorin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Mucositis
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pteroylmonoglutamic Acid Hydrolase G2 (this asset) | University College, London | P1/2 | CCC · 52 |
| Calcium Phosphate | Children's Oncology Group | P3 | BB |
| Fentanyl Sublingual Spray | INSYS Therapeutics Inc | P3 | BB |
| Palifermin | Barbara Ann Karmanos Cancer Institute | P3 | BB |
| Everolimus | Emory University | P2 | CCC |
| Folic Acid | Niels Fristrup | P2 | CCC |
| tk-112690 | Tosk, Inc. | P2 | CCC |
| Methotrexate | University College, London | P1/2 | CCC |
| Melphalan | Sherif S. Farag | P1 | CC |
+1 more in the Mucositis cohort
Other indications for Pteroylmonoglutamic Acid Hydrolase G2
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Acute Lymphoblastic Leukemia | — | P3 | BB · 64 |
| Lymphoma | — | P2 | B · 59 |
| Toxic Encephalopathy | — | P1/2 | CCC · 52 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pteroylmonoglutamic Acid Hydrolase G2 in Mucositis. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pteroylmonoglutamic-acid-hydrolase-g2-mucositis
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