(R)-(1-(4-Fluorophenyl)-6-((1-Methyl-1H-Pyrazol-4-Yl)Sulfonyl)-1,4,5,6,7,8-Hexahydro-4Ah-Pyrazolo(3,4-G)Isoquinolin-4A-Yl)(4-(Trifluoromethyl)Pyridin-2-Yl)Methanone
Cushing Syndrome
Floatz Rating
BBB72/100
Confidence
Indicative
Sponsor
Corcept Therapeutics
Modality
Small molecule
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
61High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04308590CT.gov A Study of the Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas | — | Completed | — | — | — |
NCT03697109CT.gov A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome | — | Completed | — | — | — |
NCT03604198CT.gov Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome | — | Active Not Recruiting | — | — | — |
NCT02804750CT.gov Study to Evaluate CORT125134 in Participants With Cushing's Syndrome | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Cushing Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| (R)-(1-(4-Fluorophenyl)-6-((1-Methyl-1H-Pyrazol-4-Yl)Sulfonyl)-1,4,5,6,7,8-Hexahydro-4Ah-Pyrazolo(3,4-G)Isoquinolin-4A-Yl)(4-(Trifluoromethyl)Pyridin-2-Yl)Methanone (this asset) | Corcept Therapeutics | P3 | BBB · 72 |
| Mifepristone | Corcept Therapeutics | P4 | B |
| Clofutriben | Sparrow Pharmaceuticals | P2 | CCC |
| Metyrapone | Istituto Auxologico Italiano | Unk | D |
| Semaglutide | University of Texas Southwestern Medical Center | N/A | D |
| Hydrocortisone | University Hospital, Bordeaux | N/A | NR |
Other indications for (R)-(1-(4-Fluorophenyl)-6-((1-Methyl-1H-Pyrazol-4-Yl)Sulfonyl)-1,4,5,6,7,8-Hexahydro-4Ah-Pyrazolo(3,4-G)Isoquinolin-4A-Yl)(4-(Trifluoromethyl)Pyridin-2-Yl)Methanone
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Peritoneal Neoplasm | — | P3 | BB · 64 |
| Pancreatic Ductal Adenocarcinoma | — | P3 | BB · 64 |
| Ovarian Neoplasm | — | P3 | B · 60 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Citation
Floatz Terminal. (R)-(1-(4-Fluorophenyl)-6-((1-Methyl-1H-Pyrazol-4-Yl)Sulfonyl)-1,4,5,6,7,8-Hexahydro-4Ah-Pyrazolo(3,4-G)Isoquinolin-4A-Yl)(4-(Trifluoromethyl)Pyridin-2-Yl)Methanone in Cushing Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 13, 2026. https://terminal.floatz.ai/assets/r-1-4-fluorophenyl-6-1-methyl-1h-pyrazol-4-ylsulfonyl-145678-hexahydro-4ah-pyrazolo34-gisoquinolin-4a-yl4-trifluoromethylpyridin-2-ylmethanone-cushing-syndrome
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