Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
M.D. Anderson Cancer Center
Modality
Small molecule
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03968406CT.gov Talazoparib and Radiation Therapy in Treating Patients With Locally Recurrent Gynecologic Cancers | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Vaginal Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Talazoparib (this asset) | M.D. Anderson Cancer Center | P1 | CC · 43 |
| Durvalumab | M.D. Anderson Cancer Center | P2 | B |
| Nivolumab | National Cancer Institute (NCI) | P2 | CCC |
| Plasmid Encoded Il-12 | M.D. Anderson Cancer Center | P2 | CCC |
| Dna Plasmid-Encoding Interleukin-12/Hpv Dna Plasmids Therapeutic Vaccine Medi0457 | M.D. Anderson Cancer Center | P2 | CCC |
| Ipilimumab | National Cancer Institute (NCI) | P2 | CCC |
| Dehydroepiandrosterone | Ohio State University Comprehensive Cancer Center | P2 | CCC |
| Carboplatin | Case Comprehensive Cancer Center | P1 | CCC |
| Abi-007 | National Cancer Institute (NCI) | P1 | CC |
+10 more in the Vaginal Carcinoma cohort
Other indications for Talazoparib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| BRCA2-Related Cancer Predisposition | — | P3 | BB · 68 |
| Castration-Resistant Prostate Carcinoma | — | P2 | BB · 65 |
| Her2-Receptor Negative Breast Cancer | — | P2 | BB · 64 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Talazoparib in Vaginal Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/talazoparib-vaginal-carcinoma
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