Floatz Rating
CCC48/100
Confidence
Indicative
Sponsor
Indiana University
Modality
Small molecule
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07499583CT.gov Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder | — | Not Yet Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Substance Abuse
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Teonanacatl (this asset) | Indiana University | P1/2 | CCC · 48 |
| Quetiapine | Boston Medical Center | P4 | BBB |
| Risperidone | Dartmouth-Hitchcock Medical Center | P4 | BBB |
| 17.BETA.-(1-KETOETHYL)-.DELTA. SUP(5)-ANDROSTEN-3.BETA.-OL | University of Texas Southwestern Medical Center | P4 | BB |
| Brexpiprazole | University of Massachusetts, Worcester | P4 | BB |
| Olanzapine | Augusta University | P4 | BB |
| Clozapine | Augusta University | P4 | BB |
| Oxycodone | Member Companies of the Opioid PMR Consortium | P4 | BB |
| Valproic Acid | Creighton University | P4 | BB |
+18 more in the Substance Abuse cohort
Other indications for Teonanacatl
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Depressive Disorder | — | P2 | BB · 68 |
| Major Depressive Disorder | — | P3 | BB · 65 |
| Hematopoietic And Lymphoid System Neoplasm | — | P2 | BB · 65 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Teonanacatl in Substance Abuse. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/teonanacatl-substance-abuse
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