Immunoglobulin G4, Anti-(Human Cd3 Antigen) (Recombinant Human Monoclonal Jnj-75348780 ?4-Chain), Disulfide With Recombinant Human Monoclonal Jnj-75348780 ? Chain, (229?126?),(232?129?)-Bis(Disulfide) With Immunoglobulin, Anti-(Human Sialic Acid-Binding Ig-Like Lectin 2) (Recombinant Human Single-Domain Vhh Fragment)
Myelodysplastic Syndrome
Explore 296 assets in Myelodysplastic Syndrome →Floatz Rating
C37/100
Confidence
Indicative
Sponsor
Janssen Research & Development, LLC
Modality
monoclonal_antibody
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06788509CT.gov A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring | — | Enrolling By Invitation | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Myelodysplastic Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Immunoglobulin G4, Anti-(Human Cd3 Antigen) (Recombinant Human Monoclonal Jnj-75348780 ?4-Chain), Disulfide With Recombinant Human Monoclonal Jnj-75348780 ? Chain, (229?126?),(232?129?)-Bis(Disulfide) With Immunoglobulin, Anti-(Human Sialic Acid-Binding Ig-Like Lectin 2) (Recombinant Human Single-Domain Vhh Fragment) (this asset) | Janssen Research & Development, LLC | P1 | C · 37 |
| Cytarabine | The First Affiliated Hospital of Soochow University | P4 | BB |
| Cyclophosphamide | Sawa Ito, MD | P4 | BB |
| Nivestim | City of Hope Medical Center | P4 | BB |
| Romidepsin | Sawa Ito, MD | P4 | BB |
| Fludarabine | City of Hope Medical Center | P4 | BB |
| Daunomycin | OHSU Knight Cancer Institute | P3 | BB |
| Etoposide | Memorial Sloan Kettering Cancer Center | P3 | BB |
| Busulfanum | Sawa Ito, MD | P4 | BB |
+42 more in the Myelodysplastic Syndrome cohort
Other indications for Immunoglobulin G4, Anti-(Human Cd3 Antigen) (Recombinant Human Monoclonal Jnj-75348780 ?4-Chain), Disulfide With Recombinant Human Monoclonal Jnj-75348780 ? Chain, (229?126?),(232?129?)-Bis(Disulfide) With Immunoglobulin, Anti-(Human Sialic Acid-Binding Ig-Like Lectin 2) (Recombinant Human Single-Domain Vhh Fragment)
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| B-Cell Chronic Lymphocytic Leukemia | — | P1 | CC · 44 |
| Non-Hodgkin Lymphoma | — | P1 | CC · 42 |
| Acute Myeloid Leukemia | — | P1 | CC · 41 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Immunoglobulin G4, Anti-(Human Cd3 Antigen) (Recombinant Human Monoclonal Jnj-75348780 ?4-Chain), Disulfide With Recombinant Human Monoclonal Jnj-75348780 ? Chain, (229?126?),(232?129?)-Bis(Disulfide) With Immunoglobulin, Anti-(Human Sialic Acid-Binding Ig-Like Lectin 2) (Recombinant Human Single-Domain Vhh Fragment) in Myelodysplastic Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/immunoglobulin-g4-anti-human-cd3-antigen-recombinant-human-monoclonal-jnj-75348780-4-chain-disulfide-with-recombinant-human-monoclonal-jnj-75348780-chain-229126232129-bisdisulfide-with-immunoglobulin-anti-human-sialic-acid-binding-ig-like-lectin-2-recombinant-human-single-domain-vhh-fragment-myelodysplastic-syndrome
Are you the sponsor?
Submit your data room for a Verified Rating. The public-data rating remains visible alongside.
Contact →